After two aliens discover their race is becoming extinct due to a deadly disease, they abduct the Bagge family to use as subjects who will give them antibodies that can fight off the deadly disease.
Determined to save their race from a disease that's causing them to beat themselves up uncontrollably, two alien naturalists, Captain Lazzo and Jay, abduct Courage, Muriel, and Eustace in the middle of the night.
The next morning, when Courage, Muriel, and Eustace wake up and find themselves in a spaceship, the alien naturalists explain to them that they need humans like the Bagge's in order to get from them the antibodies that will neutralize and produce immunity against the disease, since they only need help from "those who walk upright like us." Suction tubes then attach themselves to Eustace and Muriel's heads and begin to hybridize them.
Eustace and Muriel get the disease and begin to beat themselves up; suddenly, the suction tubes accidentally release themselves and spread the disease over Captain Lazzo and Jay, causing them, too, to begin beating themselves up. Eustace grabs one of the aliens' arms, which pushes a nearby button, causing the farmer to fall out of the spaceship. After an alien cat gets Courage out of the plastic wrap strapping him to the chair, the dog tries to help, but accidentally drinks the disease.
However, Courage is immune; Captain Lazzo and Jay find this out, so the latter tries to hybridize the dog. When this doesn't work, Courage hybridizes himself and begins to mutate into various things, from a corn cob to a watermelon, and manages to extract the antidote using a pipe. Muriel, Captain Lazzo, and Jay are cured; the aliens get the cure from Courage, and they return everyone to earth, except for Eustace, who is being fed mush by a female Space Dino.
- Captain Lazzo is possibly named after Mike Lazzo, the CEO of Cartoon Network during this time. He's also nodded to in "Angry Nasty People."
- The low piano music played during the title card and through nearly the entire episode is reminiscent of the piano leitmotif heard throughout "Night of the Weremole."
- This episode shares its music with "Car Broke, Phone Yes."
- The piano music also sounds like Swayzak's theme from the Toonami online game "Trapped in Hyperspace," which was on Cartoon Network's site during the time this episode aired.